Stories
| Date | Teams | Kickoff | Venue | Broadcast |
|---|---|---|---|---|
| April 14 | New England Revolution 1 (3) - 1 (1) Rhode Island FC (AET & PKs) | - | Centreville Bank Stadium; Pawtucket, R.I. | - |
| April 14 | Louisville City FC 2 - 1 Austin FC | - | Lynn Family Stadium; Louisville, Ky. | - |
| April 14 | Detroit City FC 1 - 2 Chicago Fire FC | - | Keyworth Stadium; Hamtramck, Mich. | - |
| April 14 | Westchester SC 2 - 5 New York City FC | - | Mount Vernon Memorial Field; Mount Vernon, N.Y. | - |
| April 14 | Colorado Springs Switchbacks FC 3 - 0 Sporting Kansas City | - | Weidner Field; Colorado Springs, Colo. | - |
| April 14 | Colorado Rapids 1 - 0 Union Omaha | - | DICK's Sporting Goods Park; Commerce City, Colo. | - |
| April 14 | Sacramento Republic FC 0 (8) - 0 (9) Minnesota United FC (AET & PKs) | - | Heart Health Park; Sacramento, Calif. | - |
| April 15 | FC Naples 0 - 1 Orlando City SC | - | Paradise Coast Sports Complex; Naples, Fla. | - |
| April 15 | Chattanooga FC 1 - 3 Atlanta United FC | - | Finley Stadium; Chattanooga, Tenn. | - |
| April 15 | Richmond Kickers 0 - 3 Columbus Crew | - | City Stadium; Richmond, Va. | - |
| April 15 | New York Red Bulls 3 - 1 Pittsburgh Riverhounds SC | - | Sports Illustrated Stadium; Harrison, N.J. | - |
| April 15 | Charlotte FC 6 - 0 Charlotte Independence | - | Mecklenburg County Sportsplex; Matthews, N.C. | - |
| April 15 | D.C. United 3 (5) - 3 (6) One Knoxville SC (AET & PKs) | - | Audi Field; Washington, D.C. | - |
| April 15 | St. Louis CITY SC 4 - 0 FC Tulsa | - | Energizer Park; St. Louis, Mo. | - |
| April 15 | Houston Dynamo FC 4 - 1 El Paso Locomotive FC | - | Shell Energy Stadium; Houston, Texas | - |
| April 15 | San Jose Earthquakes 2 - 0 Phoenix Rising FC | - | PayPal Park; San Jose, Calif. | - |
